The
endocrine system is a series of glands that works with the nervous system to
maintain homeostasis. Each gland
secretes specific hormones that pass through the blood to the appropriate
receptors on specific organs. The
endocrine system uses negative feedback and cycles for regulation.
The
main glands of the endocrine system are the pituitary gland, the hypothalamus,
the pancreas, the thyroid gland, and the adrenal glands. The pituitary gland is linked to the
hypothalamus to control release of pituitary hormones from the anterior
pituitary lobe. The hypothalamus
monitors levels of thyroid and growth hormones in the blood. The thyroid is located in the neck and
controls metabolic rate, regulates growth and development, and regulates the
onset of maturity. Thyroid hormones target
almost all body cells (Farabee, 2001).
The pancreas secretes insulin and glucagon. The adrenal glands are located at the top of
the kidneys and secrete epinephrine and norepinephrine, the “fight or flight”
hormones.
The
hormones used in the endocrine system are grouped into three classes: steroids, peptides, and amines. Steroid hormones pass through the plasma
membrane to bind to the nuclear membrane receptors. This produces an activated hormone-receptor
complex that binds to DNA and activates specific genes to increase the
production of proteins (Faradee, 2001).
The steroids are not stored in cells and are controlled by rate of
synthesis. Non-steroid hormones, on the
other hand, are water-soluble and bind to the plasma membrane receptors instead
of entering the cell. Non-steroid
hormones generate a chemical signal inside the target cell to trigger second
messengers to activate other intracellular chemicals in order to produce an
appropriate response (Farabee, 2001).
Peptides
and Amines are short chains of amino acids secreted by the pituitary,
parathyroid, heart, stomach, liver, and kidneys. The thyroid and adrenal medulla secrete amines
derived from the amino acid tyrosine (Farabee, 2001). Peptides and amines are stored in secretory
granules and cytoplasm to be used when needed. The hormones secreted by the endocrine system
cross over into other systems in the human body. If any of the glands in the endocrine system
are not secreting the proper amounts of a particular hormone, then it could
affect one or more of the other systems.
If any of these hormones are lacking or too plentiful, the body is
thrown out of homeostasis.
In
the Journal of Biological Physics, Conrad et al (2009) propose using
positive and negative feedback loops for restoring homeostasis in the
hypothalamus-pituitary-adrenal system.
This system is responsible for controlling stress levels and is
stimulated in the second half of the night, when a person is in deep
sleep. If a person cannot reach deep REM
sleep, the HPA system cannot restore homeostasis, and that person could suffer
depression or obesity.
Just
as the HPA system can affect mental health and weight, the pancreas can affect
the body’s ability to utilize insulin. There are a great many studies on the effect
of the endocrine system and Diabetes Mellitus.
The pancreatic islets contain
alpha cells (A cells) that secrete glucagon and beta cells (B cells) that
secrete insulin. Glucagon controls
gycogenolysis; this increases blood sugars.
These elevated blood sugars trigger the pancreas to release insulin to
lower the blood sugar levels. In type 1
diabetes mellitus, the pancreatic islets secrete too little insulin; in type 2
diabetes mellitus, the pancreatic islets secrete insulin but there is an
abnormality of insulin receptors (Thibodeau and Patton, 2008).
In
Nutrition Reviews, Wang et al (2012) discuss the protein PANDER and its
affect on beta-cell function. This could
lead to repressed glucose-stimulated insulin secretion, leading to Type 2
diabetes. Finding a way to increase the
effect of PANDER on B cell functions could help type 2 diabetics with their
insulin production and effectiveness.
In
Clinical Endocrinology, Wang et al (2012) also studied the effect of
pancreatic secretions on diabetics. In
this study, they studied the glycemic variability of non-diabetic individuals
and newly diagnosed type 2 diabetics.
They found more intraday glucose fluctuations in newly diagnosed type 2
patients and patients with impaired glucose regulation than non-diabetic
individuals (Wang et al, 2012).
These
articles teach us that the endocrine system must work properly for the body to
maintain homeostasis and avoid mild to serious diseases. Current research is still working on finding
answers to the best way to utilize the knowledge scientists already have about
the functioning of the endocrine system to help combat these diseases. The first step is to understand how the
endocrine system functions with the rest of the body to maintain homeostasis.
References:
Conrad,
Matthias; Hubold, Christian; Fischer, Bernd; Peters, Achim. (2009) Modeling the hypothalamus-pituitary-adrenal
system: homeostasis by interacting
positive and negative feedback. Journal
of Biological Physics, (2009) 35: 149-162.
Springer Science & Business Media
Thibodeau,
Gary & Patton, Kevin (2008)
Structure & Function of the Body, 13th Edition. Mosby Elsevier
Wang,
Chun; Lu, Lifang; Yang, Yanzhi; Chen, Dawei; Liu, Guanjian; Chen, Lihong; Song,
Yuanxia; He, Liping; Li, Xiujun; Tian, Hasming; Jia, Weiping; Ran, Xingwu
(2012). Glucose fluctuations in subjects
with normal glucose tolerance, impaired glucose regulation and newly diagnosed
type 2 diabetes mellitus. Clinical
Endocrinology, Vol 76, Issue 6: 810-815.
Wiley-Blackwell.
Wang,
Chunjiong; Burkhardt, Brant R; Guan, Youfei; Yang, Jichun (2012) Role of pancreatic-derived factor in type 2
diabetes: evidence from pancreatic Beta
cells and liver. Nutrition Reviews
Vol. 70(2): 100-106. Wiley-Blackwell.